MECANISMOS NEUROBIOLÓGICOS DE LA DISRUPCIÓN DEL VÍNCULO MATERNO Y SU RELACIÓN CON EL CONSUMO DE EDULCORANTES
NEUROBIOLOGICAL MECHANISMS OF MATERNAL BOND DISRUPTION AND ITS RELATIONSHIP WITH SWEETENER CONSUMPTION
DOI:
https://doi.org/10.51437/nj.v29i3.416Keywords:
Separación materna, Edulcorantes, Conducta, RecompensaAbstract
Introducción: La separación materna durante la lactancia se ha considerado un evento estresante que genera cambios neuro-morfofisiológicos y comportamentales como la ansiedad e hiperactividad, así como vulnerabilidad preferente al consumo de alcohol, sacarosa y alimentos palatables. Considerando la relación entre estrés temprano y obesidad y el aumento en el consumo de edulcorantes como alternativa al uso de glucosa, el objetivo de este trabajo fue realizar una revisión que integre los avances experimentales relacionados a la separación materna y el consumo de edulcorantes.
Materiales y métodos: Se realizó una búsqueda de las publicaciones existentes tanto en inglés como en español y se incluyeron para el análisis 12 estudios experimentales en los cuales se llevó a cabo separación materna con posterior evaluación de consumo de agua con edulcorantes.
Resultados: La separación materna es un modelo experimental que permite evaluar las consecuencias del estrés en etapas tempranas de la vida; el consumo de alimentos palatables amortigua las respuestas ante el estrés e interviene con los mecanismos neuronales de recompensa, además de funcionar como medida de conducta anhedónica mediante la prueba de preferencia a la sacarosa.
Conclusiones: Existe discrepancia entre los resultados de las diferentes investigaciones, debido a que no hay unificación entre los protocolos de separación materna y la prueba de preferencia a la sacarosa. Adicionalmente, existen factores inherentes a los sujetos, como su clasificación taxonómica y sexo, que condicionan el comportamiento de madres y sus hijos ante el estrés.
Palabras clave: Separación materna; Edulcorantes; Recompensa; Conducta
References
Unternaehrer E, Cost KT, Bouvette-Turcot AA, et al. Dissecting maternal care: Patterns of maternal parenting in a prospective cohort study. J Neuroendocrinol. 2019;31(9):DOI: 10.1111/jne.12784. doi:10.1111/jne.12784
O’Donnell MSc KA, Gaudreau PhD H, Colalillo BA S, et al. The Maternal Adversity, Vulnerability and Neurodevelopment Project: Theory and Methodology. Can J Psychiatry. 2014;59(9):497-508. DOI: 10.1177/070674371405900906. doi:10.1177/070674371405900906
Chen Y, Baram TZ. Toward understanding how early-life stress reprograms cognitive and emotional brain networks. Neuropsychopharmacology. 2016;41(1):197-206. DOI: 10.1038/npp.2015.181. doi:10.1038/npp.2015.181
McEwen BS, Gianaros PJ. Stress- and Allostasis-Induced Brain Plasticity. Annu Rev Med. 2011;62:431-445. DOI: 10.1146/annurev-med-052209-100430. doi:10.1146/annurev-med-052209-100430
Maras PM, Molet J, Chen Y, et al. Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress. Mol Psychiatry. 2014;19(7):811-822. DOI: 10.1038/mp.2014.12. doi:10.1038/mp.2014.12
Joëls M, Baram TZ. The neuro-symphony of stress. Nat Rev Neurosci. 2009;10(6):459-466. DOI: 10.1038/nrn2632. doi:10.1038/nrn2632
Tractenberg SG, Levandowski ML, de Azeredo LA, et al. An overview of maternal separation effects on behavioural outcomes in mice: Evidence from a four-stage methodological systematic review. Neurosci Biobehav Rev. 2016;68:489-503. DOI: 10.1016/j.neubiorev.2016.06.021. doi:10.1016/j.neubiorev.2016.06.021
Llorente-Berzal A, Mela V, Borcel E, et al. Neurobehavioral and metabolic long- term consequences of neonatal maternal deprivation stress and adolescent olanzapine treatment in male and female rats. Neuropharmacology. 2012;62(3):1332-1341. DOI: 10.1016/j.neuropharm.2011.07.031. doi:10.1016/j.neuropharm.2011.07.031
Molet J, Maras PM, Avishai-Eliner S, Baram TZ. Naturalistic rodent models of
chronic early-life stress. Dev Psychobiol. 2014;56(8):1675–1688.DOI: 10.1002/dev.21230. doi:10.1002/dev.21230
Chocyk A, Majcher-Maślanka I, Przyborowska A, Maćkowiak M, Wedzony K. Early-life stress increases the survival of midbrain neurons during postnatal development and enhances reward-related and anxiolytic-like behaviors in a sex-dependent fashion. Int J Dev Neurosci. 2015;44:33-47. DOI: 10.1016/j.ijdevneu.2015.05.002. doi:10.1016/j.ijdevneu.2015.05.002
de Almeida Magalhães T, Correia D, de Carvalho LM, Damasceno S, Brunialti Godard AL. Maternal separation affects expression of stress response genes and increases vulnerability to ethanol consumption. Brain Behav. 2018;8(1. DOI: 10.1002/brb3.841). doi:10.1002/brb3.841
Lee JH, Kim JY, Jahng JW. Highly palatable food during adolescence improves anxiety-like behaviors and hypothalamic-pituitary-adrenal axis dysfunction in rats that experienced neonatal maternal separation. Endocrinol Metab. 2014;29(2):169-178. DOI: 10.3803/EnM.2014.29.2.169. doi:10.3803/EnM.2014.29.2.169
Norman RE, Byambaa M, De R, Butchart A, Scott J, Vos T. The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect: A Systematic Review and Meta-Analysis. PLoS Med. 2012;9(11):DOI: 10.1371/journal.pmed.1001349. doi:10.1371/journal.pmed.1001349
Shin SH, Miller DP, Teicher MH. Exposure to childhood neglect and physical abuse and developmental trajectories of heavy episodic drinking from early adolescence into young adulthood. Drug Alcohol Depend. 2013;127:31-38. DOI: 10.1016/j.drugalcdep.2012.06.005. doi:10.1016/j.drugalcdep.2012.06.005
Stern A, Agnew-Blais J, Danese A, et al. Associations between abuse/neglect and ADHD from childhood to young adulthood: A prospective nationally- representative twin study. Child Abus Negl. 2018;81:274-285. DOI: 10.1016/j.chiabu.2018.04.025. doi:10.1016/j.chiabu.2018.04.025
Oliver G, Wardle J, Gibson EL. Stress and food choice: A laboratory study. Psychosom Med. 2000;62(2):853-865. DOI: 10.1097/00006842-200011000- 00016. doi:10.1097/00006842-200011000-00016
Singh M. Mood, food, and obesity. Front Psychol. 2014;5:925. DOI: 10.3389/fpsyg.2014.00925. doi:10.3389/fpsyg.2014.00925
Raineki C, Lucion AB, Weinberg J. Neonatal handling: An overview of the positive and negative effects. Dev Psychobiol. 2014;56(8):1613-1625. DOI: 10.1002/dev.21241. doi:10.1002/dev.21241
Nylander I, Roman E. Is the rodent maternal separation model a valid and effective model for studies on the early-life impact on ethanol consumption? Psychopharmacology (Berl). 2013;229(4):555-569. DOI: 10.1007/s00213-013- 3217-3. doi:10.1007/s00213-013-3217-3
Orso R, Creutzberg KC, Wearick-Silva LE, et al. How Early Life Stress Impact Maternal Care: A Systematic Review of Rodent Studies. Front Behav Neurosci. 2019;13:197. DOI: 10.3389/fnbeh.2019.00197. doi:10.3389/fnbeh.2019.00197
Mizoguchi H, Fukumoto K, Sakamoto G, et al. Maternal separation as a risk factor for aggravation of neuropathic pain in later life in mice. Behav Brain Res. 2019;359:942-949. DOI: 10.1016/j.bbr.2018.06.015. doi:10.1016/j.bbr.2018.06.015
Holmes A, Le Guisquet AM, Vogel E, Millstein RA, Leman S, Belzung C. Early life genetic, epigenetic and environmental factors shaping emotionality in rodents. Neurosci Biobehav Rev. 2005;29(8):1335-1346. DOI: 10.1016/j.neubiorev.2005.04.012. doi:10.1016/j.neubiorev.2005.04.012
Michaels CC, Holtzman SG. Neonatal stress and litter composition alter sucrose intake in both rat dam and offspring. Physiol Behav. 2006;89(5):735-741. DOI: 10.1016/j.physbeh.2006.08.015. doi:10.1016/j.physbeh.2006.08.015
Maniam J, Morris MJ. Long-term postpartum anxiety and depression-like behavior in mother rats subjected to maternal separation are ameliorated by palatable high fat diet. Behav Brain Res. 2010;208(1):72-79. DOI: 10.1016/j.bbr.2009.11.005. doi:10.1016/j.bbr.2009.11.005
Cruz FC, Quadros IM, Da S. Planeta C, Miczek KA. Maternal separation stress in male mice: Long-term increases in alcohol intake. Psychopharmacology (Berl). 2008;201(3):459-468. DOI: 10.1007/s00213-008-1307-4. doi:10.1007/s00213-
-1307-4
Millstein RA, Holmes A. Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains. Neurosci Biobehav Rev. 2007;31(1):3-17. DOI: 10.1016/j.neubiorev.2006.05.003. doi:10.1016/j.neubiorev.2006.05.003
Marmendal M, Roman E, Eriksson CJP, Nylander I, Fahlke C. Maternal separation alters maternal care, but has minor effects on behavior and brain opioid peptides in adult offspring. Dev Psychobiol. 2004;45(3):140-152. DOI: 10.1002/dev.20027. doi:10.1002/dev.20027
Hancock S, Grant V. Early Maternal Separation Increases Symptoms of Activity- Based Anorexia in Male and Female Rats. J Exp Psychol Anim Behav Process. 2009;35(5):394-406. DOI: 10.1037/a0014736. doi:10.1037/a0014736
Silveira PP, Portella AK, Clemente Z, et al. Neonatal handling alters feeding behavior of adult rats. Physiol Behav. 2004;50(5):739-745. DOI: 10.1016/j.physbeh.2003.12.009. doi:10.1016/j.physbeh.2003.12.009
Ryu V, Lee JH, Yoo SB, Gu XF, Moon YW, Jahng JW. Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation. Int J Obes. 2008;32:1355-1362. DOI: 10.1038/ijo.2008.108. doi:10.1038/ijo.2008.108
Husum H, Mathé AA. Early life stress changes concentrations of neuropeptide Y and corticotropin-releasing hormone in adult rat brain. Lithium treatment modifies these changes. Neuropsychopharmacology. 2002;27:156-164. DOI: 10.1016/S0893-133X(02)00363-9. doi:10.1016/S0893-133X(02)00363-9
Kim HJ, Lee JH, Choi SH, Lee YS, Jahng JW. Fasting-induced increases of arcuate NPY mRNA and plasma corticosterone are blunted in the rat experienced neonatal maternal separation. Neuropeptides. 2005;39(6):587-594. DOI: 10.1016/j.npep.2005.09.003. doi:10.1016/j.npep.2005.09.003
Own LS, Patel PD. Maternal behavior and offspring resiliency to maternal separation in c57bl/6 mice. Horm Behav. 2013;63(3):411-417. DOI: 10.1016/j.yhbeh.2012.11.010. doi:10.1016/j.yhbeh.2012.11.010
Biggio F, Pisu MG, Garau A, et al. Maternal separation attenuates the effect of
adolescent social isolation on HPA axis responsiveness in adult rats. Eur Neuropsychopharmacol. 2014;24(7):1152-1161. DOI: 10.1016/j.euroneuro.2014.03.009. doi:10.1016/j.euroneuro.2014.03.009
Couto-Pereira N de S, Ferreira CF, Lampert C, et al. Neonatal interventions differently affect maternal care quality and have sexually dimorphic developmental effects on corticosterone secretion. Int J Dev Neurosci. 2016;55:72-81. DOI: 10.1016/j.ijdevneu.2016.10.001. doi:10.1016/j.ijdevneu.2016.10.001
Romeo RD, Mueller A, Sisti HM, Ogawa S, McEwen BS, Brake WG. Anxiety and fear behaviors in adult male and female C57BL/6 mice are modulated by maternal separation. Horm Behav. 2003;43(5):561-567. DOI: 10.1016/S0018- 506X(03)00063-1. doi:10.1016/S0018-506X(03)00063-1
Yamamoto T. Central mechanisms of roles of taste in reward and eating. Acta Physiol Hung. 2008;95(2):165-186. DOI: 10.1556/APhysiol.95.2008.2.2. doi:10.1556/APhysiol.95.2008.2.2
Hu H. Reward and Aversion. Annu Rev Neurosci. 2016;39:297-324. DOI: 10.1146/annurev-neuro-070815-014106. doi:10.1146/annurev-neuro-070815- 014106
Parker G, Parker I, Brotchie H. Mood state effects of chocolate. J Affect Disord. 2006;92(2-3):149-159. DOI: 10.1016/j.jad.2006.02.007. doi:10.1016/j.jad.2006.02.007
Weinstock M. Prenatal stressors in rodents: Effects on behavior. Neurobiol Stress. 2017;6:3-13. DOI: 10.1016/j.ynstr.2016.08.004. doi:10.1016/j.ynstr.2016.08.004
Hoffman KL. What can animal models tell us about depressive disorders? In: Modeling Neuropsychiatric Disorders in Laboratory Animals. ; 2016:35-86. DOI: 10.1016/b978-0-08-100099-1.00002-9. doi:10.1016/b978-0-08-100099-1.00002- 9
Amiri S, Amini-Khoei H, Mohammadi-Asl A, et al. Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal
separation model of mouse. Physiol Behav. 2016;163:107-114. DOI: 10.1016/j.physbeh.2016.04.052. doi:10.1016/j.physbeh.2016.04.052
Klug M, van den Buuse M. Chronic cannabinoid treatment during young adulthood induces sex-specific behavioural deficits in maternally separated rats. Behav Brain Res. 2012;233(2):305-313. DOI: 10.1016/j.bbr.2012.05.019. doi:10.1016/j.bbr.2012.05.019
Wang Q, Dong X, Wang Y, et al. Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice. Int J Dev Neurosci. 2017;62:37-45. DOI: 10.1016/j.ijdevneu.2017.07.007. doi:10.1016/j.ijdevneu.2017.07.007
Sadeghi M, Peeri M, Hosseini MJ. Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats. Physiol Behav. 2016;163:177- 183. DOI: 10.1016/j.physbeh.2016.05.017. doi:10.1016/j.physbeh.2016.05.017
Hui J jie, Zhang Z jun, Liu S shan, et al. Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study. Behav Brain Res. 2011;217(1):122-127. DOI: 10.1016/j.bbr.2010.10.014. doi:10.1016/j.bbr.2010.10.014
Michaels CC, Holtzman SG. Enhanced sensitivity to naltrexone-induced drinking suppression of fluid intake and sucrose consumption in maternally separated rats. Pharmacol Biochem Behav. 2007;86(4):784-796. DOI: 10.1016/j.pbb.2007.03.007. doi:10.1016/j.pbb.2007.03.007
Ferreira CF, Bernardi JR, Krolow R, et al. Vulnerability to dietary n-3 polyunsaturated fatty acid deficiency after exposure to early stress in rats. Pharmacol Biochem Behav. 2013;107:11-19. DOI: 10.1016/j.pbb.2013.03.006. doi:10.1016/j.pbb.2013.03.006
Aya-Ramos L. Efecto de la separación materna durante la lactancia en ratas, sobre el consumo de edulcorantes, el peso corporal y la locomoción [Maestría]. Published online 2015.
Caicedo Mera JC. Efectos del estrés inducido por separación materna durante la lactancia. Evaluación de probables mecanismos involucrados en la expresión diferencialasociada al género [Doctorado]. Published online 2015.
Lara Avella JJ. Estudio retrospectivo del vínculo madre-hijo surante el primer año de vida y su relacióncon el desarrollo del pre-escolar [Maestría]. Published online 2016.
Congreso De Colombia 8 de noviembre de 2006. Ley 1098 de 2006 1/118. https://www.icbf.gov.co/cargues/avance/docs/ley_1098_2006.htm
Social M de S y P. Licencia de Maternidad. Published 2020. https://www.minsalud.gov.co/salud/Paginas/LicenciaMaternidad.aspx
DANE. Medición de empleo informal y seguridad social. Published 2020.
https://www.dane.gov.co/files/investigaciones/boletines/ech/ech_informalidad
/bol_ech_informalidad_may20.pdf
El Tiempo. Cada día abandonan 2 niños en Colombia.https://www.eltiempo.com/archivo/documento/MAM-4960102. Published November 12, 2011.
Instituto Colombiano de Bienestar Familiar. Resumen Ejecutivo Encuesta Nacional de La Situación Nutricional En Colombia, ENSIN 2010 [Executive Summary National Survey of Nutrition Situation in Colombia, ENSIN 2010].; 2010.
La Fleur SE, Houshyar H, Roy M, Dallman MF. Choice of lard, but not total lard calories, damps adrenocorticotropin responses to restraint. Endocrinology. 2005;146(5):2193-2199. DOI: 10.1210/en.2004-1603. doi:10.1210/en.2004-1603
Iemolo A, Valenza M, Tozier L, et al. Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats. Behav Pharmacol. 2012;23:593-602. DOI: 10.1097/FBP.0b013e328357697f. doi:10.1097/FBP.0b013e328357697f
Mela DJ. Determinants of food choice: relationships with obesity and weight control. Obes Res. 2001;9(11):DOI: 10.1038/oby.2001.127. doi:10.1038/oby.2001.127
Teegarden SL, Bale TL. Effects of stress on dietary preference and intake are dependent on access and stress sensitivity. Physiol Behav. 2008;93(4-5):713- 723. DOI: 10.1016/j.physbeh.2007.11.030. doi:10.1016/j.physbeh.2007.11.030
Levine AS, Kotz CM, Gosnell BA. Sugars: hedonic aspects, neuroregulation, and energy balance. Am J Clin Nutr. 2003;78(4):834-842. DOI:10.1093/ajcn/78.4.834s. doi:10.1093/ajcn/78.4.834s
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